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PGES / PTGES Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O14684 |
| Reactivity | Human, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Dilution | IHC-P (5-10 µg/ml) |
| Gene ID | 9536 |
|---|---|
| Other Names | Prostaglandin E synthase, 5.3.99.3, Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 protein, PTGES, MGST1L1, MPGES1, PGES, PIG12 |
| Target/Specificity | Human PTGES. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | PGES / PTGES Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTGES |
|---|---|
| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione- dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). |
| Cellular Location | Membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment |
| Volume | 100 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
References
Polyak K.,et al.Nature 389:300-306(1997).
Jakobsson P.-J.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:7220-7225(1999).
Forsberg L.,et al.FEBS Lett. 471:78-82(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
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