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Prostaglandin E Synthase Rabbit mAb
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- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O14684 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 17102 Da |
| Gene ID | 9536 |
|---|---|
| Other Names | PTGES |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | PTGES |
|---|---|
| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione- dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). |
| Cellular Location | Membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP75956
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