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GCNT3 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O95395 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Dilution | IHC-P (2.5 µg/ml) |
| Gene ID | 9245 |
|---|---|
| Other Names | Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase 3, 2.4.1.102, 2.4.1.150, C2GnT-mucin type, C2GnT-M, hC2GnT-M, Core 2/core 4 beta-1, 6-N-acetylglucosaminyltransferase, C2/4GnT, GCNT3 |
| Target/Specificity | Human GCNT3. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NEK8 (60%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GCNT3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GCNT3 |
|---|---|
| Function | Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I- branching enzyme activity by converting linear into branched poly-N- acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
References
Yeh J.-C.,et al.J. Biol. Chem. 274:3215-3221(1999).
Schwientek T.,et al.J. Biol. Chem. 274:4504-4512(1999).
Tan S.,et al.Am. J. Respir. Cell Mol. Biol. 36:737-745(2007).
Ishibashi Y.,et al.Glycoconj. J. 22:53-62(2005).
Huang M.-C.,et al.Oncogene 25:3267-3276(2006).
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