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GCNT3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O95395 |
| Other Accession | Q8CH87, Q5JCT0, NP_004742.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50864 Da |
| Antigen Region | 390-418 aa |
| Gene ID | 9245 |
|---|---|
| Other Names | Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase 3, C2GnT-mucin type, C2GnT-M, hC2GnT-M, Core 2/core 4 beta-1, 6-N-acetylglucosaminyltransferase, C2/4GnT, GCNT3 |
| Target/Specificity | This GCNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human GCNT3. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GCNT3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GCNT3 |
|---|---|
| Function | Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I- branching enzyme activity by converting linear into branched poly-N- acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.
References
Tan, S., et al. Am. J. Respir. Cell Mol. Biol. 36(6):737-745(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Huang, M.C., et al. Oncogene 25(23):3267-3276(2006)
Beum, P.V., et al. Am. J. Respir. Cell Mol. Biol. 29(1):48-56(2003)
Schwientek, T., et al. J. Biol. Chem. 274(8):4504-4512(1999)
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