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CBLC Antibody (aa444-458)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E, IP |
|---|---|
| Primary Accession | Q9ULV8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Dilution | ELISA (1:10000-1:50000), IHC-P (5 µg/ml), WB (1:500-1:3000) |
| Gene ID | 23624 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase CBL-C, 6.3.2.-, RING finger protein 57, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C, CBLC, CBL3, RNF57 |
| Target/Specificity | Amino acids 444-458 of Human Cbl-c. |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | CBLC Antibody (aa444-458) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBLC |
|---|---|
| Synonyms | CBL3, RNF57 |
| Function | Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. |
| Tissue Location | Ubiquitous.. |
| Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
References
Kim M.,et al.Gene 239:145-154(1999).
Keane M.M.,et al.Oncogene 18:3365-3375(1999).
Kim M.,et al.Oncogene 23:1645-1655(2004).
Tsui C.C.,et al.J. Neurosci. 28:8789-8800(2008).
Ryan P.E.,et al.J. Biol. Chem. 285:23687-23698(2010).
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