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NOS1 / nNOS Antibody (aa1422-1433)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, IP |
|---|---|
| Primary Accession | P29475 |
| Reactivity | Human, Mouse, Rabbit, Monkey, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 161kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 4842 |
|---|---|
| Other Names | Nitric oxide synthase, brain, 1.14.13.39, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS, NOS1 |
| Target/Specificity | Human nNOS amino acids 1422-1433 (ESKKDTDEVFSS)1,2 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NOS1 / nNOS Antibody (aa1422-1433) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOS1 (HGNC:7872) |
|---|---|
| Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. |
| Cellular Location | Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z0J4}; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P29476}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity) In neurons, enriched in dendritic spines (By similarity) {ECO:0000250|UniProtKB:P29476, ECO:0000250|UniProtKB:Q9Z0J4} |
| Tissue Location | Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland |
| Volume | Array |
Provided below are standard protocols that you may find useful for product applications.
Background
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
References
Hall A.V.,et al.J. Biol. Chem. 269:33082-33090(1994).
Fujisawa H.,et al.J. Neurochem. 63:140-145(1994).
Nakane M.,et al.FEBS Lett. 316:175-180(1993).
Park C.-S.,et al.Cell. Mol. Neurobiol. 16:499-515(1996).
Wang Y.,et al.J. Biol. Chem. 272:11392-11401(1997).
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