ARHGEF11 Antibody (aa1-50)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | O15085 |
Reactivity | Human, Mouse, Rat, Monkey, Chicken, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 168kDa |
Dilution | IHC-P (10 µg/ml), WB (0.1-0.5 µg/ml), |
Gene ID | 9826 |
---|---|
Other Names | Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF, ARHGEF11, KIAA0380 |
Target/Specificity | A portion of amino acids 1-50 of human ARHGEF11 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | ARHGEF11 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ARHGEF11 |
---|---|
Synonyms | KIAA0380 |
Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. |
Cellular Location | Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation |
Tissue Location | Ubiquitously expressed. |
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Background
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
References
Nagase T.,et al.DNA Res. 4:141-150(1997).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ruemenapp U.,et al.FEBS Lett. 459:313-318(1999).
Fukuhara S.,et al.J. Biol. Chem. 274:5868-5879(1999).
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