TFAP2C / AP2 Gamma Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q92754 |
Reactivity | Human, Rabbit, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 49kDa |
Dilution | ELISA (1:128000), IHC-P (2.5 µg/ml), |
Gene ID | 7022 |
---|---|
Other Names | Transcription factor AP-2 gamma, AP2-gamma, Activating enhancer-binding protein 2 gamma, Transcription factor ERF-1, TFAP2C |
Target/Specificity | Human TFAP2C / AP2 Gamma. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | TFAP2C / AP2 Gamma Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TFAP2C |
---|---|
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
Cellular Location | Nucleus. |
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Background
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
References
Williamson J.A.,et al.Genomics 35:262-264(1996).
McPherson L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4342-4347(1997).
Haselton M.D.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
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