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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Anti-Wnt-Pathway (plus Lgr5) Antibodies   >   ACVR1C / ALK7 Antibody (N-Terminus)   

ACVR1C / ALK7 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ACVR1C / ALK7 Antibody (N-Terminus) ALS12646
    Anti-ACVR1 antibody IHC of human adrenal.
    detail
  • IHC - ACVR1C / ALK7 Antibody (N-Terminus) ALS12646
    Anti-ACVR1 antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8NER5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Dilution IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 130399
Other Names Activin receptor type-1C, 2.7.11.30, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (HGNC:18123)
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsACVR1C / ALK7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACVR1C (HGNC:18123)
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Cellular Location Membrane; Single- pass type I membrane protein
Tissue Location Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

References

Bondestam J.,et al.Cytogenet. Cell Genet. 95:157-162(2001).
Roberts H.J.,et al.Biol. Reprod. 68:1719-1726(2003).
Hillier L.W.,et al.Nature 434:724-731(2005).
Xu G.,et al.J. Clin. Endocrinol. Metab. 89:5523-5534(2004).
Greenman C.,et al.Nature 446:153-158(2007).

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$ 467.50
Cat# ALS12646
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