FEZ1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q99689 |
Reactivity | Human, Rat, Rabbit, Hamster, Monkey, Horse, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (1:128000) |
Gene ID | 9638 |
---|---|
Other Names | Fasciculation and elongation protein zeta-1, Zygin I, Zygin-1, FEZ1 |
Target/Specificity | Human FEZ1. This antibody is expected to recognize isoform 1 (NP_005094.1) only. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | FEZ1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FEZ1 |
---|---|
Function | May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). |
Tissue Location | Mainly expressed in brain. |
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Background
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
References
Bloom L.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:3414-3419(1997).
Sugita S.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Okumura F.,et al.J. Biol. Chem. 279:53533-53543(2004).
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