PDE4B Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q07343 |
Reactivity | Human, Mouse |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 83kDa |
Dilution | ELISA (1:8000), IHC-P (5 µg/ml), WB (1:8000) |
Gene ID | 5142 |
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Other Names | cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, 3.1.4.53, DPDE4, PDE32, PDE4B, DPDE4 |
Target/Specificity | Human PDE4B. This antibody is expected to recognise all reported isoforms (NP_002591.2, NP_001032418.1, NP_001032416.1 and NP_001032417.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | PDE4B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PDE4B (HGNC:8781) |
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Synonyms | DPDE4 |
Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
Cellular Location | [Isoform PDE4B5]: Cytoplasm. Cell membrane |
Tissue Location | Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
References
Obernolte R.,et al.Gene 129:239-247(1993).
Bolger G.,et al.Mol. Cell. Biol. 13:6558-6571(1993).
Huston E.,et al.Biochem. J. 328:549-558(1997).
McLaughlin M.M.,et al.J. Biol. Chem. 268:6470-6476(1993).
Cheung Y.F.,et al.J. Pharmacol. Exp. Ther. 322:600-609(2007).
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