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Anti-PDE4B/C/D Antibody

     
  • WB - Anti-PDE4B/C/D Antibody AP53693
    Western blot analysis of PDE4B/C/D expression in HeLa (A) whole cell lysates.
    detail
  • IH - Anti-PDE4B/C/D Antibody AP53693
    Immunohistochemical analysis of PDE4B/C/D staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q07343
Other Accession Q08493, Q08499
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 83343 Da
Additional Information
Gene ID 5142
Other Names PDE4B; DPDE4; cAMP-specific 3', 5'-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4C; DPDE1; cAMP-specific 3', 5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4D; DPDE3; cAMP-specific 3', 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43
Target/Specificity Recognizes endogenous levels of PDE4B/C/D protein.
Dilution WB~~1/500 - 1/1000
IH~~1/50 - 1/200
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PDE4B (HGNC:8781)
Synonyms DPDE4
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Cellular Location [Isoform PDE4B5]: Cytoplasm. Cell membrane
Tissue Location Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015)
Research Areas
Citations (0)
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Background

Rabbit polyclonal antibody to PDE4B/C/D

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$ 350.00
Cat# AP53693
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