Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
HTR3A / 5-HT3A Receptor Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P46098 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 55kDa |
| Dilution | ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 3359 |
|---|---|
| Other Names | 5-hydroxytryptamine receptor 3A, 5-HT3-A, 5-HT3A, 5-hydroxytryptamine receptor 3, 5-HT-3, 5-HT3R, Serotonin receptor 3A, Serotonin-gated ion channel receptor, HTR3A, 5HT3R, HTR3 |
| Target/Specificity | Human HTR3A / 5-HT3A. This antibody is expected to recognise all three reported isoforms (NP_998786.2; NP_000860.2; NP_001155244.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | HTR3A / 5-HT3A Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTR3A (HGNC:5297) |
|---|---|
| Synonyms | 5HT3R, HTR3 |
| Function | Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation- selective channel complexes, which when activated cause fast, depolarizing responses in neurons. |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23979}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23979} |
| Tissue Location | Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
References
Miyake A.,et al.Mol. Pharmacol. 48:407-416(1995).
Belelli D.,et al.Mol. Pharmacol. 48:1054-1062(1995).
Bruess M.,et al.Ann. N. Y. Acad. Sci. 861:234-235(1998).
Bruess M.,et al.Neuropharmacology 39:308-315(2000).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
