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AGTR1 / AT1 Receptor Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P30556 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 185 |
|---|---|
| Other Names | Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B |
| Target/Specificity | Human AGTR1 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | AGTR1 / AT1 Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGTR1 (HGNC:336) |
|---|---|
| Function | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:1567413, PubMed:8987975, PubMed:15611106, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Liver, lung, adrenal and adrenocortical adenomas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
References
Mauzy C.A.,et al.Biochem. Biophys. Res. Commun. 186:277-284(1992).
Furuta H.,et al.Biochem. Biophys. Res. Commun. 183:8-13(1992).
Bergsma D.J.,et al.Biochem. Biophys. Res. Commun. 183:989-995(1992).
Takayanagi R.,et al.Biochem. Biophys. Res. Commun. 183:910-916(1992).
Curnow K.M.,et al.Mol. Endocrinol. 6:1113-1118(1992).
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