|Application ||IHC-P, WB, FC, IF, E|
|Other Accession||P34976, P30555, NP_114438.1, NP_114038.1|
|Calculated MW||41061 Da|
|Antigen Region||211-240 aa|
|Other Names||Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B|
|Target/Specificity||This AGTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human AGTR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGTR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:1567413, PubMed:8987975, PubMed:15611106, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Liver, lung, adrenal and adrenocortical adenomas.|
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Provided below are standard protocols that you may find useful for product applications.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].
Xu, M., et al. Atherosclerosis 213(1):191-199(2010)
Niu, W., et al. Hypertens. Res. 33(11):1137-1143(2010)
Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Schuur, M., et al. J. Neurol. Neurosurg. Psychiatr. (2010) In press :
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