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EDF1 / MBF1 Antibody (aa2-14)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O60869 |
| Reactivity | Human, Mouse, Rat, Monkey, Pig, Chicken, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 16kDa |
| Dilution | IHC-P (3.75-7.5 µg/ml) |
| Gene ID | 8721 |
|---|---|
| Other Names | Endothelial differentiation-related factor 1, EDF-1, Multiprotein-bridging factor 1, MBF1, EDF1 |
| Target/Specificity | Human EDF1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | EDF1 / MBF1 Antibody (aa2-14) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EDF1 |
|---|---|
| Function | Transcriptional coactivator stimulating NR5A1 and ligand- dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone- induced cardiomyocytes hypertrophy and lipid metabolism. |
| Cellular Location | Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin |
| Tissue Location | Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
References
Dragoni I.,et al.J. Biol. Chem. 273:31119-31124(1998).
Kabe Y.,et al.J. Biol. Chem. 274:34196-34202(1999).
Kalnine N.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
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