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PAPPA2 / Pappalysin 2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | Q9BXP8 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 199kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 60676 |
|---|---|
| Other Names | Pappalysin-2, 3.4.24.-, Pregnancy-associated plasma protein A2, PAPP-A2, Pregnancy-associated plasma protein E1, PAPP-E, PAPPA2, PLAC3 |
| Target/Specificity | Human PAPPA2 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | PAPPA2 / Pappalysin 2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAPPA2 |
|---|---|
| Synonyms | PLAC3 |
| Function | Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.
References
Overgaard M.T.,et al.J. Biol. Chem. 276:21849-21853(2001).
Page N.M.,et al.Placenta 22:681-687(2001).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Farr M.,et al.Biochim. Biophys. Acta 1493:356-362(2000).
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