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ATXN1 / SCA1 Antibody (aa742-791)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, E |
|---|---|
| Primary Accession | P54253 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 87kDa |
| Dilution | ELISA (1:5000), IF (1:100-1:500), IHC-P (5 µg/ml) |
| Gene ID | 6310 |
|---|---|
| Other Names | Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1 |
| Target/Specificity | Ataxin 1 (Ab-776) Antibody detects endogenous levels of total Ataxin 1 protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | ATXN1 / SCA1 Antibody (aa742-791) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATXN1 |
|---|---|
| Synonyms | ATX1, SCA1 |
| Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). |
| Cellular Location | Cytoplasm. Nucleus Note=Colocalizes with USP7 in the nucleus |
| Tissue Location | Widely expressed throughout the body. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
References
Banfi S.,et al.Nat. Genet. 7:513-519(1994).
Mungall A.J.,et al.Nature 425:805-811(2003).
Quan F.,et al.Hum. Mol. Genet. 4:2411-2413(1995).
Burright E.N.,et al.Hum. Mol. Genet. 6:513-518(1997).
Matilla A.,et al.Nature 389:974-978(1997).
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