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TRPC4 Antibody (aa930-947, clone S77-15)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, IP |
|---|---|
| Primary Accession | Q9UBN4 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | S77-15 |
| Calculated MW | 112kDa |
| Dilution | ICC (0.1-1 µg/ml), IHC-P (1:50), IP (1-10 µg/ml), WB (1-10 µg/ml) , |
| Gene ID | 7223 |
|---|---|
| Other Names | Short transient receptor potential channel 4, TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4 |
| Target/Specificity | Detects ~110 kD protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | TRPC4 Antibody (aa930-947, clone S77-15) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPC4 |
|---|---|
| Function | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor |
| Tissue Location | Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
References
McKay R.R.,et al.Biochem. J. 351:735-746(2000).
Mery L.,et al.FEBS Lett. 487:377-383(2001).
Schaefer M.,et al.J. Biol. Chem. 277:3752-3759(2002).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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