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GRIK5 / KA2 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q16478 |
| Reactivity | Human, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 109kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), |
| Gene ID | 2901 |
|---|---|
| Other Names | Glutamate receptor ionotropic, kainate 5, GluK5, Excitatory amino acid receptor 2, EAA2, Glutamate receptor KA-2, KA2, GRIK5, GRIK2 |
| Target/Specificity | Human GRIK5. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | GRIK5 / KA2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRIK5 |
|---|---|
| Synonyms | GRIK2 |
| Function | Ionotropic glutamate receptor that functions as a cation- permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1 and GRIK2 subunits (PubMed:1321949, PubMed:14511640, PubMed:8730589). Can form functional heteromeric receptors with GRIK3 (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q61626}; Multi-pass membrane protein. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q61626}; Multi-pass membrane protein. Note=Association with GRIK2 is required for its cell membrane localization and channel activity |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD.
References
Kamboj R.K.,et al.Mol. Pharmacol. 42:10-15(1992).
Langer A.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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