CLDN4 / Claudin 4 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | O14493 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 22kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 1364 |
---|---|
Other Names | Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4, CPER, CPETR1, WBSCR8 |
Target/Specificity | Human CLDN4 / Claudin 4. At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | CLDN4 / Claudin 4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLDN4 |
---|---|
Function | Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:O35054}. Cell membrane; Multi-pass membrane protein. Note=CLDN4 is required for tight junction localization in the kidney. {ECO:0000250|UniProtKB:O35054} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a major role in tight junction-specific obliteration of the intercellular space.
References
Katahira J.,et al.J. Biol. Chem. 272:26652-26658(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Tanaka M.,et al.J. Biol. Chem. 280:42375-42382(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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