|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||144851 Da|
|Dilution||IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||SIK3, KIAA0999, L19, QSK, Salt-inducible kinase 3, SIK-3, SIK family kinase 3|
|Target/Specificity||Human SIK3. At least three isoforms of SIK3 are known to exist; this antibody will detect two isoforms. SIK3 antibody is predicted to not cross-react with SIK1 and SIK2.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||SIK3 / QSK Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).|
|Cellular Location||Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.|
|Tissue Location||Expressed in chondrocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Lizcano J.M.,et al.EMBO J. 23:833-843(2004).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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