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SIK3 / QSK Antibody (C-Terminus)

Chicken Polyclonal Antibody

     
  • IHC - SIK3 / QSK Antibody (C-Terminus) ALS16619
    Anti-SIK3 / QSK antibody IHC staining of human breast.
    detail
  • IF - SIK3 / QSK Antibody (C-Terminus) ALS16619
    Immunofluorescence of SIK3 in rat brain cells with SIK3 antibody at 20 µg/mL.
    detail
  • WB - SIK3 / QSK Antibody (C-Terminus) ALS16619
    Western blot analysis of SIK3 in rat brain tissue lysate with SIK3 antibody at 1 ug/ml in (A)...
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9Y2K2
Other Accession 23387
Reactivity Human, Mouse, Rat
Host Chicken
Clonality Polyclonal
Isotype IgY
Calculated MW 144851 Da
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 23387
Other Names SIK3, KIAA0999, L19, QSK, Salt-inducible kinase 3, SIK-3, SIK family kinase 3
Target/Specificity Human SIK3. At least three isoforms of SIK3 are known to exist; this antibody will detect two isoforms. SIK3 antibody is predicted to not cross-react with SIK1 and SIK2.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSIK3 / QSK Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIK3 (HGNC:29165)
Function Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).
Cellular Location Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.
Tissue Location Expressed in chondrocytes.
Research Areas
Citations (0)
citation

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References

Lizcano J.M.,et al.EMBO J. 23:833-843(2004).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS16619
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