SIK3 / QSK Antibody (C-Terminus)
Chicken Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9Y2K2 |
Other Accession | 23387 |
Reactivity | Human, Mouse, Rat |
Host | Chicken |
Clonality | Polyclonal |
Isotype | IgY |
Calculated MW | 144851 Da |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml), |
Gene ID | 23387 |
---|---|
Other Names | SIK3, KIAA0999, L19, QSK, Salt-inducible kinase 3, SIK-3, SIK family kinase 3 |
Target/Specificity | Human SIK3. At least three isoforms of SIK3 are known to exist; this antibody will detect two isoforms. SIK3 antibody is predicted to not cross-react with SIK1 and SIK2. |
Reconstitution & Storage | PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | SIK3 / QSK Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SIK3 (HGNC:29165) |
---|---|
Function | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). |
Cellular Location | Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. |
Tissue Location | Expressed in chondrocytes. |
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Provided below are standard protocols that you may find useful for product applications.
References
Lizcano J.M.,et al.EMBO J. 23:833-843(2004).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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