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KIAA0999 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KIAA0999 Antibody (C-term) AP11541b
    KIAA0999 Antibody (C-term) (Cat. #AP11541b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the KIAA0999 antibody detected the KIAA0999 protein (arrow).
    detail
  • FC - KIAA0999 Antibody (C-term) AP11541b
    KIAA0999 Antibody (C-term) (Cat. #AP11541b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q9Y2K2
Other Accession NP_079440.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 144851 Da
Antigen Region 1233-1263 aa
Additional Information
Gene ID 23387
Other Names Serine/threonine-protein kinase SIK3, Salt-inducible kinase 3, SIK-3, Serine/threonine-protein kinase QSK, SIK3, KIAA0999, QSK
Target/Specificity This KIAA0999 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1233-1263 amino acids from the C-terminal region of human KIAA0999.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKIAA0999 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIK3 (HGNC:29165)
Function Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).
Cellular Location Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.
Tissue Location Expressed in chondrocytes.
Research Areas
Citations ( 0 )

Background

The specific function of the protein remains unknown.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Huang, C.J., et al. J. Cell. Mol. Med. 12 (5B), 1936-1943 (2008) :
Hashimoto, Y.K., et al. J. Cell. Biochem. 104(5):1724-1739(2008)
Kooner, J.S., et al. Nat. Genet. 40(2):149-151(2008)

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$ 365.00
$ 140.00
Cat# AP11541b
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