KIAA0999 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
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Primary Accession | Q9Y2K2 |
Other Accession | NP_079440.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 144851 Da |
Antigen Region | 1233-1263 aa |
Gene ID | 23387 |
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Other Names | Serine/threonine-protein kinase SIK3, Salt-inducible kinase 3, SIK-3, Serine/threonine-protein kinase QSK, SIK3, KIAA0999, QSK |
Target/Specificity | This KIAA0999 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1233-1263 amino acids from the C-terminal region of human KIAA0999. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KIAA0999 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SIK3 (HGNC:29165) |
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Function | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). |
Cellular Location | Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. |
Tissue Location | Expressed in chondrocytes. |
Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of the protein remains unknown.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Huang, C.J., et al. J. Cell. Mol. Med. 12 (5B), 1936-1943 (2008) :
Hashimoto, Y.K., et al. J. Cell. Biochem. 104(5):1724-1739(2008)
Kooner, J.S., et al. Nat. Genet. 40(2):149-151(2008)
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