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HIBCH Antibody (clone 5C5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC |
|---|---|
| Primary Accession | Q6NVY1 |
| Other Accession | 26275 |
| Reactivity | Human, Rat, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 5C5 |
| Calculated MW | 43482 Da |
| Dilution | Flo (1:100), IF (1:100), IHC-P (10 µg/ml), WB (1:2000), |
| Gene ID | 26275 |
|---|---|
| Other Names | HIBCH, HIB-CoA hydrolase, HIBYL-CoA-H, HIBYLCOAH |
| Target/Specificity | Human HIBCH |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | HIBCH Antibody (clone 5C5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HIBCH |
|---|---|
| Function | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level). Not detected in lung |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
References
Hawes J.W.,et al.J. Biol. Chem. 271:26430-26434(1996).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Choudhary C.,et al.Science 325:834-840(2009).
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