Fibulin-3 / EFEMP1 Antibody (clone 1D9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, FC |
---|---|
Primary Accession | Q12805 |
Other Accession | 2202 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a |
Clone Names | 1D9 |
Calculated MW | 54641 Da |
Dilution | Flo (1:100), IHC-P (10 µg/ml), WB (1:200 - 1:500), |
Gene ID | 2202 |
---|---|
Other Names | EFEMP1, DHRD, Extracellular protein S1-5, FBNL, FBLN3, Fibrillin-like protein, Fibrillin-like, MLVT, S1-5, MTLV, DRAD, FIBL-3, Fibulin-3 |
Target/Specificity | Human Fibulin-3 / EFEMP1 |
Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
Precautions | Fibulin-3 / EFEMP1 Antibody (clone 1D9) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EFEMP1 |
---|---|
Synonyms | FBLN3, FBNL |
Function | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
Cellular Location | Secreted, extracellular space. Secreted, extracellular space, extracellular matrix Note=Localizes to the lamina propria underneath the olfactory epithelium. |
Tissue Location | In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina |
Volume | 50 µl |
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Background
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
References
Lecka-Czernik B.,et al.Mol. Cell. Biol. 15:120-128(1995).
Ikegawa S.,et al.Genomics 35:590-592(1996).
Giltay R.,et al.Matrix Biol. 18:469-480(1999).
Sauer C.G.,et al.Ophthalmic Genet. 22:27-34(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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