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HHEX / HEX Antibody (clone 3F4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF |
|---|---|
| Primary Accession | Q03014 |
| Other Accession | 3087 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 3F4 |
| Calculated MW | 30022 Da |
| Dilution | IF (1:100), IHC-P (2.5 µg/ml), |
| Gene ID | 3087 |
|---|---|
| Other Names | HHEX, HEX, HMPH, Homeobox protein HEX, HOX11L-PEN, PRHX, Homeobox protein PRH, PRH |
| Target/Specificity | Human HHEX / HEX |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | HHEX / HEX Antibody (clone 3F4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HHEX |
|---|---|
| Synonyms | HEX, PRH, PRHX |
| Function | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT- signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P43120}. Nucleus, nuclear body. Cytoplasm |
| Tissue Location | Liver and promyelocytic leukemia cell line HL-60. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
References
Crompton M.R.,et al.Nucleic Acids Res. 20:5661-5667(1992).
Hromas R.A.,et al.Biochem. Biophys. Res. Commun. 195:976-983(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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