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HHEX Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HHEX Antibody (C-term) AP18467b
    HHEX Antibody (C-term) (Cat. #AP18467b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the HHEX antibody detected the HHEX protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q03014
Other Accession NP_002720.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 30022 Da
Antigen Region 244-270 aa
Additional Information
Gene ID 3087
Other Names Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX
Target/Specificity This HHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-270 amino acids from the C-terminal region of human HHEX.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHHEX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HHEX
Synonyms HEX, PRH, PRHX
Function Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT- signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P43120}. Nucleus, nuclear body. Cytoplasm
Tissue Location Liver and promyelocytic leukemia cell line HL-60.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.

References

Heni, M., et al. Diabetes 59(12):3247-3252(2010)
Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)
Reitz, C., et al. Neurobiol. Aging (2010) In press :
Gaudet, M.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2106-2109(2010)
Gupta, V., et al. Ann. Hum. Genet. 74(4):361-368(2010)

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$ 182.50
$ 70.00
Cat# AP18467b
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