HHEX Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q03014 |
Other Accession | NP_002720.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 30022 Da |
Antigen Region | 244-270 aa |
Gene ID | 3087 |
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Other Names | Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX |
Target/Specificity | This HHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-270 amino acids from the C-terminal region of human HHEX. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HHEX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HHEX |
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Synonyms | HEX, PRH, PRHX |
Function | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT- signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P43120}. Nucleus, nuclear body. Cytoplasm |
Tissue Location | Liver and promyelocytic leukemia cell line HL-60. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
References
Heni, M., et al. Diabetes 59(12):3247-3252(2010)
Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)
Reitz, C., et al. Neurobiol. Aging (2010) In press :
Gaudet, M.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2106-2109(2010)
Gupta, V., et al. Ann. Hum. Genet. 74(4):361-368(2010)
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