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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CD53 Antibody (clone MEM-53)
Anti-CD53 Antibody (clone MEM-53)
Mouse Anti Human Monoclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IP, FC |
|---|---|
| Primary Accession | P19397 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | MEM-53 |
| Calculated MW | 24341 Da |
| Dilution | Flo (1:10 - 1:25), IHC-Fr, IHC-P (10 µg/ml), IP, WB |
| Gene ID | 963 |
|---|---|
| Alias Symbol | CD53 |
| Other Names | CD53, CD53 antigen, CD53 molecule, CD53 tetraspan antigen, Cell surface antigen, Leukocyte surface antigen CD53, Transmembrane glycoprotein, Tetraspanin-25, Tspan-25, CD53 glycoprotein, Cell surface glycoprotein CD53, MOX44, TSPAN25 |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-CD53 Antibody (clone MEM-53) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD53 |
|---|---|
| Synonyms | MOX44, TSPAN25 |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:28487417). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:32974937, PubMed:35767951). Plays a role in the activation of monocytes and B-cells (PubMed:8335905). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (By similarity). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (PubMed:28487417). Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (By similarity). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment (By similarity). |
| Cellular Location | Cell membrane. Cell junction {ECO:0000250|UniProtKB:Q61451}. Membrane; Multi-pass membrane protein. Synapse. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250|UniProtKB:Q61451} |
| Tissue Location | B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells |
Research Areas
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