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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-Betaglycan / TGFBR3 Antibody (Extracellular Domain, clone D11G10)
Anti-Betaglycan / TGFBR3 Antibody (Extracellular Domain, clone D11G10)
Rabbit Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | Q03167 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Clone Names | D11G10 |
| Calculated MW | 93499 Da |
| Dilution | IHC-P (1:100), IP (1:50), WB (1:1000) |
| Gene ID | 7049 |
|---|---|
| Alias Symbol | TGFBR3 |
| Other Names | TGFBR3, Betaglycan, BGCAN, TGF-beta receptor type 3, TGF-beta receptor type III, TGFR-3, Betaglycan proteoglycan, Tgf-beta receptors type iii |
| Target/Specificity | Endogenous levels of total TGF-b receptor III. |
| Reconstitution & Storage | Purified |
| Precautions | Anti-Betaglycan / TGFBR3 Antibody (Extracellular Domain, clone D11G10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFBR3 (HGNC:11774) |
|---|---|
| Function | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta- arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342} |
Research Areas
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$ 566.50
Cat# ALS17999
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