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> home > Products > Primary Antibodies > Signal Transduction > Anti-NEI3 / NEIL3 Antibody (aa491-540)
Anti-NEI3 / NEIL3 Antibody (aa491-540)
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TAT5 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 67769 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 55247 |
|---|---|
| Alias Symbol | NEIL3 |
| Other Names | NEIL3, DNA glycosylase/AP lyase Neil3, FGP2, DNA glycosylase FPG2, DNA glycosylase hFPG2, FPG2, HFPG2, Endonuclease 8-like 3, Endonuclease VIII-like 3, HNEI3, Nei-like protein 3, NEI3 |
| Target/Specificity | NEIL3 Antibody detects endogenous levels of total NEIL3 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-NEI3 / NEIL3 Antibody (aa491-540) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEIL3 |
|---|---|
| Function | DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). No activity on 8-oxoG detected (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:A0A1L8HU22}. Note=Recruited to replication stress sites via interaction with ubiquitinated CMG helicase {ECO:0000250|UniProtKB:A0A1L8HU22} |
| Tissue Location | Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. |
Research Areas
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$ 555.50
Cat# ALS18360
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