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LTB Antibody (C-term)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q06643 |
| Other Accession | Q9TSV8, NP_002332.1, NP_033666.1 |
| Reactivity | Human |
| Predicted | Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 399CT9.3.4 |
| Calculated MW | 25390 Da |
| Antigen Region | 199-227 aa |
| Gene ID | 4050 |
|---|---|
| Other Names | Lymphotoxin-beta, LT-beta, Tumor necrosis factor C, TNF-C, Tumor necrosis factor ligand superfamily member 3, LTB, TNFC, TNFSF3 |
| Target/Specificity | This LTB antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the C-terminal region of human LTB. |
| Dilution | WB~~1:500~1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LTB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTB |
|---|---|
| Synonyms | TNFC, TNFSF3 |
| Function | Cytokine that binds to LTBR/TNFRSF3 (PubMed:24248355). May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. |
| Cellular Location | Membrane; Single-pass type II membrane protein |
| Tissue Location | Spleen and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Young, J., et al. Cytokine 51(1):78-86(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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