|Application ||WB, E|
|Calculated MW||83550 Da|
|Other Names||Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1, 18.104.22.168, Lysyl hydroxylase 1, LH1, PLOD1, LLH, PLOD|
|Target/Specificity||This PLOD1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 61-94 amino acids from the C-terminal region of human PLOD1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLOD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable).|
|Cellular Location||Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side|
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Provided below are standard protocols that you may find useful for product applications.
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Hautala T.,et al.Genomics 13:62-69(1992).
Heikkinen J.,et al.Genomics 24:464-471(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Pirskanen A.,et al.J. Biol. Chem. 271:9398-9402(1996).
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