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PLOD1 Antibody (C-term)
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q02809 |
| Other Accession | Q9R0E2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2b,κ |
| Clone/Animal Names | 2114CT109.4.71.73 |
| Calculated MW | 83550 Da |
| Gene ID | 5351 |
|---|---|
| Other Names | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1, 1.14.11.4, Lysyl hydroxylase 1, LH1, PLOD1, LLH, PLOD |
| Target/Specificity | This PLOD1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 61-94 amino acids from the C-terminal region of human PLOD1. |
| Dilution | WB~~1:4000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLOD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLOD1 |
|---|---|
| Synonyms | LLH, PLOD |
| Function | Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). |
| Cellular Location | Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
References
Hautala T.,et al.Genomics 13:62-69(1992).
Heikkinen J.,et al.Genomics 24:464-471(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Pirskanen A.,et al.J. Biol. Chem. 271:9398-9402(1996).
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