Adenylate Cyclase III Antibody
Rabbit polyclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF |
---|---|
Primary Accession | P21932 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | 160, 200 KDa |
Gene ID | 64508 |
---|---|
Gene Name | ADCY3 |
Other Names | Adenylate cyclase type 3, ATP pyrophosphate-lyase 3, Adenylate cyclase type III, AC-III, Adenylate cyclase, olfactive type, Adenylyl cyclase 3, AC3, Adcy3 |
Target/Specificity | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
Dilution | WB~~ 1:2000 IF~~ 1:500 |
Format | Affinity purified rabbit serum. |
Antibody Specificity | Specific for the ~160 kDa adenylate cyclase III protein. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Adenylate Cyclase III Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Adenylate cyclase is the enzyme which produces the “second messenger” signaling molecule, cAMP from ATP. Type III adenylate cyclase is localized to the membranes surrounding neuronal cilia. Much is currently unknown about the function of primary cilia in vertebrates, however, recent work has begun to explore their role in neuronal signaling and neurogenesis (Fuchs and Schwark, 2004; Louvi and Grove 2011).
References
Fuchs JL, Schwark HD. (2004) Neuronal primary cilia: a review. Cell Biol Int. 28:111-8.
Louvi A and Grove EA. (2011) Cilia in the CNS: the quiet organelle claims center stage. Neuron 69:1046-1060
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