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FOX3 (NeuN) Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | A6NFN3 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a |
| Clone Names | 1B7 |
| Calculated MW | 46/48 KDa |
| Gene ID | 146713 |
|---|---|
| Gene Name | RBFOX3 |
| Other Names | RNA binding protein fox-1 homolog 3, Fox-1 homolog C, RBFOX3 |
| Target/Specificity | Recombinant protein taken from the N-terminus of human FOX3 expressed in and purified from E. Coli. |
| Dilution | WB~~ 1:2000 IF~~ 1:500 |
| Format | Affinity purified from tissue culture supernatant. 100 µl PBS + 10 mM sodium azide. |
| Antibody Specificity | Specific for the ~46/48k FOX3 protein doublet. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOX3 (NeuN) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
FOX3, also known as NeuN and hexaribonucleotide binding protein 3, is a neuron-specific RNA binding nuclear protein involved in the regulation of pre-mRNA alternative splicing (Kim et al., 2009). FOX3 dependent alternative splicing of Numb has recently been shown to play an important role in the progression of neuronal differentiation during vertebrate development (Kim et al., 2013).
References
Kim KK, Adelstein RS, Kawamoto S (2009) Identification of neuronal nuclei (NeuN) as Fox-3, a new
member of the Fox-1 gene family of splicing factors. J Biol Chem. Nov 6; 284(45):31052-61.
Kim KK, Nam J, Mukouyama YS, Kawamoto S. (2013) Rbfox3-regulated alternative splicing of Numb
promotes neuronal differentiation during development. J Cell Biol. Feb 18;200(4):443-58
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