PAX4 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O43316 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3C12 |
Isotype | IgG1 |
Calculated MW | 38kDa |
Description | This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. |
Immunogen | Purified recombinant fragment of human PAX4 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Other Names | Paired box protein Pax-4, PAX4 |
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Dilution | E~~1/10000 WB~~1/500 - 1/2000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PAX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PAX4 |
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Function | Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. PLoS One. 2008 Mar 12;3(3):e1783. 2. Diabetes Res Clin Pract. 2008 Sep;81(3):365-9.
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