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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MSI2 Antibody   

MSI2 Antibody

Purified Mouse Monoclonal Antibody

  • E - MSI2 Antibody AO1530a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • WB - MSI2 Antibody AO1530a
    Figure 1: Western blot analysis using MSI2 mouse mAb against NTERA-2 (1), SW620 (2) and T47D (3) cell lysate.
  • IHC - MSI2 Antibody AO1530a
    Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and cerebellum tissues (right) using MSI2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96DH6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2C11
Isotype IgG1
Calculated MW 35kDa
Description Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous; detected at low levels.
Immunogen Purified recombinant fragment of human MSI2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 124540
Other Names RNA-binding protein Musashi homolog 2, Musashi-2, MSI2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMSI2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSI2
Function RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Cellular Location Cytoplasm. Note=Associated with polysomes.
Tissue Location Ubiquitous; detected at low levels.
Research Areas
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1. Am J Hum Genet. 2009 Nov;85(5):628-42. 2. Haematologica. 2008 Dec;93(12):1903-7.

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$ 385.00
Cat# AO1530a
Availability: 7-10 days
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