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MAP3K2 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | Q9Y2U5 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4B4 |
| Isotype | IgG1 |
| Calculated MW | 70kDa |
| Description | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. |
| Immunogen | Purified recombinant fragment of human MAP3K2 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 10746 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 2, 2.7.11.25, MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2, MAP3K2, MAPKKK2, MEKK2 |
| Dilution | WB~~1/500 - 1/2000 ICC~~N/A E~~1/10000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP3K2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K2 |
|---|---|
| Synonyms | MAPKKK2, MEKK2 |
| Function | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and- run dynamics. |
| Cellular Location | Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Clin Cancer Res. 2009 Sep 1;15(17):5541-51. 2. J Biol Chem. 2009 May 15;284(20):13533-41.
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$ 385.00
Cat# AO1623a
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