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NR6A1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | Q15406 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4G8 |
| Isotype | IgG1 |
| Calculated MW | 54.3kDa |
| Description | This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants. |
| Immunogen | Purified recombinant fragment of human NR6A1 (AA: 65-118) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 2649 |
|---|---|
| Other Names | Nuclear receptor subfamily 6 group A member 1, Germ cell nuclear factor, GCNF, hGCNF, Retinoid receptor-related testis-specific receptor, RTR, hRTR, NR6A1, GCNF |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IF~~1/400 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NR6A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NR6A1 |
|---|---|
| Synonyms | GCNF {ECO:0000303|PubMed:26769970} |
| Function | Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3' (PubMed:26769970). Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4: binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation (PubMed:26769970). Involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Shows highest expression in the germ cells of the adult testis. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Biochem Biophys Res Commun. 2010 Dec 10;403(2):178-83.2.Cell. 2005 Sep 23;122(6):957-68.
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$ 385.00
Cat# AO1742a
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