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CTNNBL1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | Q8WYA6 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1E4F5 |
| Isotype | IgG1 |
| Calculated MW | 65.2kDa |
| Description | The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. |
| Immunogen | Purified recombinant fragment of human CTNNBL1 (AA: 390-557) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
| Gene ID | 56259 |
|---|---|
| Other Names | Beta-catenin-like protein 1, Nuclear-associated protein, NAP, Testis development protein NYD-SP19, CTNNBL1, C20orf33 |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTNNBL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTNNBL1 |
|---|---|
| Synonyms | C20orf33 |
| Function | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799). |
| Cellular Location | [Isoform 1]: Nucleus. |
| Tissue Location | Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. ; ;
References
1. J Biol Chem. 2011 May 13;286(19):17091-102.2. Mol Cell. 2008 Aug 22;31(4):474-84.
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