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CTNNBL1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WYA6 |
| Other Accession | NP_110517.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65173 Da |
| Antigen Region | 16-43 aa |
| Gene ID | 56259 |
|---|---|
| Other Names | Beta-catenin-like protein 1, Nuclear-associated protein, NAP, Testis development protein NYD-SP19, CTNNBL1, C20orf33 |
| Target/Specificity | This CTNNBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human CTNNBL1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTNNBL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTNNBL1 |
|---|---|
| Synonyms | C20orf33 |
| Function | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799). |
| Cellular Location | [Isoform 1]: Nucleus. |
| Tissue Location | Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. [provided by RefSeq].
References
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Badiglian Filho, L., et al. Oncol. Rep. 21(2):313-320(2009)
Andreasen, C.H., et al. BMC Med. Genet. 10, 17 (2009) :
Vogel, C.I., et al. BMC Med. Genet. 10, 14 (2009) :
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