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Mouse Monoclonal Antibody to AKT3
Purified Mouse Monoclonal Antibody
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- BACKGROUND
Application 
| WB, FC, ICC, E |
|---|---|
| Primary Accession | P19022 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5H7C3 |
| Isotype | Mouse IgG2a |
| Calculated MW | 55.8kDa |
| Description | This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.; |
| Immunogen | Purified recombinant fragment of human AKT3 (AA: 37-150) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 ICC: 1/50 - 1/250 FCM: 1/200 - 1/400 |
| Gene ID | 1000 |
|---|---|
| Other Names | CDHN; NCAD; CD325; CDw325 |
| Dilution | WB~~1:1000 FC~~1:10~50 ICC~~N/A E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to AKT3 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDH2 |
|---|---|
| Synonyms | CDHN, NCAD |
| Function | Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15116}. Cell junction. Cell surface {ECO:0000250|UniProtKB:P15116}. Cell junction, desmosome {ECO:0000250|UniProtKB:P15116}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P15116}. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes {ECO:0000250|UniProtKB:P15116} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Mol Med Rep. 2015 Aug;12(2):2999-3006. ; 2.BMC Cancer. 2013 Jun 26;13:309. ;
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$ 435.00
Cat# AO2397a
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