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Mouse Monoclonal Antibody to CDCP1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9H5V8 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5G3H11 |
| Isotype | Mouse IgG1 |
| Calculated MW | 93kDa |
| Description | This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. ; |
| Immunogen | Purified recombinant fragment of human CDCP1 (AA: 692-836) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 |
| Gene ID | 64866 |
|---|---|
| Other Names | CD318; TRASK; SIMA135 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to CDCP1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDCP1 |
|---|---|
| Synonyms | TRASK |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. |
| Cellular Location | [Isoform 1]: Cell membrane; Single- pass membrane protein. Note=Shedding may also lead to a soluble peptide |
| Tissue Location | Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Cell Rep. 2015 Apr 28;11(4):564-76. ; 2.BMC Cancer. 2014 Oct 9;14:754. ;
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$ 385.00
Cat# AO2415a
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