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Mouse Monoclonal Antibody to NEFM
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC, E |
|---|---|
| Primary Accession | P07197 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1B6B12 |
| Isotype | Mouse IgG1 |
| Calculated MW | 102.5kDa |
| Description | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. ; |
| Immunogen | Purified recombinant fragment of human NEFM (AA: 779-916) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 ICC: 1/50 - 1/200 FCM: 1/200 - 1/400 |
| Gene ID | 4741 |
|---|---|
| Other Names | NFM; NEF3; NF-M |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to NEFM is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEFM |
|---|---|
| Synonyms | NEF3, NFM |
| Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08553}. Cell projection, axon {ECO:0000250|UniProtKB:P08553} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Neuropathol Exp Neurol. 2004 Jul;63(7):759-74. ; 2.Neurosci Lett. 2003 Nov 13;351(2):125-9.;
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$ 385.00
Cat# AO2474a
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