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MLXIP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9HAP2 |
| Other Accession | Q2VPU4, NP_055753.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101185 Da |
| Antigen Region | 72-100 aa |
| Gene ID | 22877 |
|---|---|
| Other Names | MLX-interacting protein, Class E basic helix-loop-helix protein 36, bHLHe36, Transcriptional activator MondoA, MLXIP (HGNC:17055) |
| Target/Specificity | This MLXIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the N-terminal region of human MLXIP. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLXIP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MLXIP (HGNC:17055) |
|---|---|
| Function | Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875} |
| Tissue Location | Widely expressed in adult tissues. Most abundant in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).
References
Peterson, C.W., et al. Mol. Cell. Biol. 30(12):2887-2895(2010)
Kaadige, M.R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14878-14883(2009)
Stoltzman, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(19):6912-6917(2008)
Sans, C.L., et al. Mol. Cell. Biol. 26(13):4863-4871(2006)
Bornhauser, B.C., et al. J. Biol. Chem. 278(37):35412-35420(2003)
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