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CLIC6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q96NY7 |
| Other Accession | Q811Q2, Q8BHB9, NP_444507.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73012 Da |
| Antigen Region | 539-565 aa |
| Gene ID | 54102 |
|---|---|
| Other Names | Chloride intracellular channel protein 6, Parchorin, CLIC6, CLIC1L |
| Target/Specificity | This CLIC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-565 amino acids from the Central region of human CLIC6. |
| Dilution | FC~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLIC6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLIC6 {ECO:0000303|PubMed:37838179, ECO:0000312|HGNC:HGNC:2065} |
|---|---|
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane; Single-pass membrane protein Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity) |
| Tissue Location | Expressed in brain, placenta, pancreas, liver, lung, heart, kidney, liver, spleen, soleus muscle, and brown fat |
Provided below are standard protocols that you may find useful for product applications.
Background
CLIC6 is a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.
References
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Friedli, M., et al. Gene 320, 31-40 (2003) :
Strippoli, P., et al. Mamm. Genome 13(8):456-462(2002)
Scanlan, M.J., et al. Cancer Immun. 1, 4 (2001) :
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