- CITATIONS: 3
|Application ||FC, WB, IHC-P, E|
|Other Accession||Q9GKY0, NP_009016.1|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||34986 Da|
|Antigen Region||280-308 aa|
|Other Names||Follistatin-related protein 1, Follistatin-like protein 1, FSTL1, FRP|
|Target/Specificity||This FSTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-308 amino acids from the C-terminal region of human FSTL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FSTL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).|
|Tissue Location||Overexpressed in synovial tissues from rheumatoid arthritis (PubMed:15638044).|
Provided below are standard protocols that you may find useful for product applications.
Kai, N., et al. Brain Res. 1073-1074, 60-70 (2006) :
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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