PARS2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, FC, E |
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Primary Accession | Q7L3T8 |
Other Accession | NP_689481.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53263 Da |
Antigen Region | 390-417 aa |
Gene ID | 25973 |
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Other Names | Probable proline--tRNA ligase, mitochondrial, Prolyl-tRNA synthetase, ProRS, PARS2 |
Target/Specificity | This PARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-417 amino acids from the C-terminal region of human PARS2. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PARS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PARS2 (HGNC:30563) |
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Function | Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). |
Cellular Location | Mitochondrion matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Bonnefond, L., et al. Biochemistry 44(12):4805-4816(2005)
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