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CTSZ Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UBR2 |
| Other Accession | NP_001327.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33868 Da |
| Antigen Region | 22-50 aa |
| Gene ID | 1522 |
|---|---|
| Other Names | Cathepsin Z, Cathepsin P, Cathepsin X, CTSZ |
| Target/Specificity | This CTSZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CTSZ. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTSZ Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTSZ |
|---|---|
| Function | Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). |
| Cellular Location | Lysosome. |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
References
Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)
Cooke, G.S., et al. Am. J. Respir. Crit. Care Med. 178(2):203-207(2008)
Harris, S.E., et al. BMC Genet. 8, 43 (2007) :
Lechner, A.M., et al. J. Biol. Chem. 281(51):39588-39597(2006)
Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
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