HDAC11 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q96DB2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39183 Da |
Antigen Region | 313-345 aa |
Gene ID | 79885 |
---|---|
Other Names | Histone deacetylase 11, HD11, HDAC11 |
Target/Specificity | This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HDAC11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HDAC11 |
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Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
Cellular Location | Nucleus. |
Tissue Location | Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis |
Provided below are standard protocols that you may find useful for product applications.
Background
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
References
Keedy, K.S. et al. J Virol. May; 83(10): 4749?756(2009).
Voelter-Mahlknecht S, et al., Int J Mol Med. 2005 Oct;16(4):589-98.
Bradbury CA, et al., Leukemia. 2005 Oct;19(10):1751-9.
Gregoretti IV, et al., J Mol Biol. 2004 Apr 16;338(1):17-31.
Gao, L., et al., J. Biol. Chem. 277(28):25748-25755 (2002).
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