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OR10J5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8NHC4 |
| Other Accession | NP_001004469.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34401 Da |
| Antigen Region | 243-270 aa |
| Gene ID | 127385 |
|---|---|
| Other Names | Olfactory receptor 10J5, Olfactory receptor OR1-28, OR10J5 |
| Target/Specificity | This OR10J5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-270 amino acids from the C-terminal region of human OR10J5. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OR10J5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OR10J5 (HGNC:14993) |
|---|---|
| Function | Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+) (PubMed:25791473, PubMed:28842679). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (By similarity). Acts also as a regulator of angiogenesis (PubMed:25791473). Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679). May be involved in sperm chemotaxis and motility (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in both the aorta, the coronary artery and umbilical vein endothelial cells (HUVECs) (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
References
Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :
Malnic, B., et al. Proc. Natl. Acad. Sci. U.S.A. 101(8):2584-2589(2004)
Gilad, Y., et al. Am. J. Hum. Genet. 73(3):489-501(2003)
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